1. What’s New ?

This is the page that reports ZcurveHub updates and their latest work. You can bookmark this page to keep up with the latest news.

1.1. Released version 1.6.0

1.1.1. Software Update:

Date: 2025-06-05
[1] Fixed the program crash issue caused by the memory management error of ZcurvePlotter.z_curve;
[2] Sliding window AT-fraction and GC-fraction are added as auxiliary curves for ZcurvePlotter;
[3] The calculation process of fitting the Z-curve was optimized to enhance robustness;
[4] The calculation of genome order numbers for AT disparity and GC disparity were revised to better find the segmentation points;

1.1.2. Web Service Update:

Date: 2025-06-02
[1] Added auxiliary curve (AT/GC fraction/skew) plotting options to Z-curve Plotter;
[2] NCBI Sequence Viewer was added for Z-curve Plotter and Z-curve Segmenter;
[3] Z-curve Segmenter can now display GC content curves and jump directly to the corresponding segment;
[4] The Z-curve database was updated;

1.2. Released version 1.5.12

1.2.1. Software Update:

[1] Sliding window calculated AT skew and GC skew have been added into APIs of ZcurvePlotter;
[2] Sliding window calculated AT fraction and GC fraction have been added into APIs of ZcurvePlotter;
[3] The directory of NCBI download cache is migrated from ncbi_acc_download to ncbi_cache;
[4] No longer use ncbi-acc-download as the downloader. From 1.5.12, it use Entrez directly;
[5] Add support for Python 3.12 and macOS systems.

1.3. Released version 1.5.11

1.3.1. Software Update:

Date: 2025-04-14
[1] Fixed a Bug that could cause the C++ core to crash;
[2] Adjusted the ZcurveSegmenter parameter name to prevent confusion;
[3] Added the feature to handle subsequences intercepted from genomes for ZcurveSegmenter;
[4] Updated the description of the Web Server in the documentation;
[5] Frequently used API functions have been modified some return’s type from Python list to Numpy ndarray;
[6] The missing examples in the document have been completed.

1.3.2. Web Service Update:

Date: 2025-04-17
[1] The 2D mode of Z-curve Plotter now allows users to select up to 4 components for each sequence;
[2] The floating labels on the 3D mode curve can now display position information;

1.4. Released version 1.5.10

1.4.1. Software Update:

Date: 2025-04-01
[1] Fixed the errors in the document and standard documentation for ZcurveSegmenter;
[2] Add version restrictions for dependent packages to prevent incorrect configuration;
[3] Optimized C++ module compilation process, supports installation on unsupported systems;
[4] Fixed a bug where plot sampling intervals could not be set automatically;
[5] The output saving process of command line program is optimized;

1.5. Released version 1.5.9

1.5.1. Software Update:

Date: 2025-03-15
[1] Fixed incorrect display of date and version information in __init__ module comments;
[2] Removes the constraint that ZcurveBuilder’s input data type must be Iterable;
[3] Fixed ZcurveBuilder compatibility issues with models in sklearn;
[4] Fixed incorrect display of formulas in README documentation;
[5] Fixed an issue where jump links in documentation did not work;
[6] The GenBank files will only be downloaded when users need to extract CDS;
[7] Fixed an issue where the graphical interface could not be displayed properly on Linux systems;