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## Citation
The paper on this work has not yet been published. If you would like to cite this software in your work, please contact us to discuss alternatives.

Zhang Z, Lin Y, Luo H, Gao F. ZcurveHub: an updated large-scale Z curve knowledgebase with scalable genome analysis framework.

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## Reference
[1] &nbsp; Guo FB, Ou HY, Zhang CT. ZCURVE: a new system for recognizing protein-coding genes in bacterial and archaeal genomes. Nucleic Acids Res. 2003 Mar 15;31(6):1780-9. doi: 10.1093/nar/gkg254. [[Pubmed]](https://pubmed.ncbi.nlm.nih.gov/12626720/)  

[2] &nbsp; Zhang CT, Zhang R. A nucleotide composition constraint of genome sequences. Comput Biol Chem. 2004 Apr;28(2):149-53. doi: 10.1016/j.compbiolchem.2004.02.002. [[Pubmed]](https://pubmed.ncbi.nlm.nih.gov/15130543/)  

[3] &nbsp; Zhang CT, Gao F, Zhang R. Segmentation algorithm for DNA sequences. Phys Rev E Stat Nonlin Soft Matter Phys. 2005 Oct;72(4 Pt 1):041917. doi: 10.1103/PhysRevE.72.041917. [[Pubmed]](https://pubmed.ncbi.nlm.nih.gov/16383430/)  

[4] &nbsp; Gao F, Zhang CT. GC-Profile: a web-based tool for visualizing and analyzing the variation of GC content in genomic sequences. Nucleic Acids Res. 2006 Jul 1;34(Web Server issue):W686-91. doi: 10.1093/nar/gkl040. [[Pubmed]](https://pubmed.ncbi.nlm.nih.gov/16845098/)  

[5] &nbsp; Zhang R, Zhang CT. A Brief Review: The Z-curve Theory and its Application in Genome Analysis. Curr Genomics. 2014 Apr;15(2):78-94. doi: 10.2174/1389202915999140328162433. [[Pubmed]](https://pubmed.ncbi.nlm.nih.gov/24822026/)  

[6] &nbsp; Hua ZG, Lin Y, Yuan YZ, Yang DC, Wei W, Guo FB. ZCURVE 3.0: identify prokaryotic genes with higher accuracy as well as automatically and accurately select essential genes. Nucleic Acids Res. 2015 Jul 1;43(W1):W85-90. doi: 10.1093/nar/gkv491. Epub 2015 May 14. [[Pubmed]](https://pubmed.ncbi.nlm.nih.gov/25977299/)  

[7] &nbsp; Wang D, Lai FL, Gao F. Ori-Finder 3: a web server for genome-wide prediction of replication origins in Saccharomyces cerevisiae. Brief Bioinform. 2021 May 20;22(3):bbaa182. doi: 10.1093/bib/bbaa182. [[Pubmed]](https://pubmed.ncbi.nlm.nih.gov/34020544/)  

[8] &nbsp; Lai FL, Gao F. GC-Profile 2.0: an extended web server for the prediction and visualization of CpG islands. Bioinformatics. 2022 Mar 4;38(6):1738-1740. doi: 10.1093/bioinformatics/btab864.  [[Pubmed]](https://pubmed.ncbi.nlm.nih.gov/34954794/)  

[9] Yin ZN, Lai FL, Gao F. Unveiling human origins of replication using deep learning: accurate prediction and comprehensive analysis. Brief Bioinform. 2023 Nov 22;25(1):bbad432. doi: 10.1093/bib/bbad432.  [[Pubmed]](https://pubmed.ncbi.nlm.nih.gov/38008420/)  

[10] Geng YQ, Lai FL, Luo H, Gao F. Nmix: a hybrid deep learning model for precise prediction of 2'-O-methylation sites based on multi-feature fusion and ensemble learning. Brief Bioinform. 2024 Sep 23;25(6):bbae601. doi: 10.1093/bib/bbae601. [[Pubmed]](https://pubmed.ncbi.nlm.nih.gov/39550226/)

## Acknowledgement <a id="title8"></a>
The authors wishes to thank Prof. Chun-Ting Zhang, who proposed the Z-curve theory and his collaborators Ren Zhang, Ling-Ling Chen, Hong-Yu Ou and Feng-Biao Guo for their significant contributions to the development of the theory.  <p align="right">— Staff of TUBIC, 2025-06-25</p>